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Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?
journal contribution
posted on 2023-05-20, 21:07 authored by Gunasegaran KarupiahGunasegaran Karupiah, Blanden, RVThe neurovirulent strain of vaccinia virus, VV-WR, or recombinants derived from VV-WR, cause highly productive infection of murine ovaries, but infection could be partially inhibited in vivo using an antiserum to asialo-GM1 (as-GM1). In vitro analysis by flow cytometry revealed that murine ovarian cells expressed a cell surface antigen identical to or cross-reactive with as-GM1. The capacity of VV-WR to infect murine ovaries appears to depend in part upon as-GM1 expression on ovarian cells.
History
Publication title
Immunology and Cell BiologyVolume
68Issue
Pt 5Pagination
343-6ISSN
0818-9641Department/School
Tasmanian School of MedicinePublisher
Blackwell Publishing AsiaPlace of publication
54 University St, P O Box 378, Carlton, Australia, Victoria, 3053Rights statement
Copyright 1990 BlackwellRepository Status
- Restricted