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Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?

Citation

Karupiah, G and Blanden, RV, Anti-asialo-GM1 inhibits vaccinia virus infection of murine ovaries: asialo-GM1 as an additional virus receptor?, Immunology and Cell Biology, 68, (Pt 5) pp. 343-6. ISSN 0818-9641 (1990) [Refereed Article]


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DOI: doi:10.1038/icb.1990.46

Abstract

The neurovirulent strain of vaccinia virus, VV-WR, or recombinants derived from VV-WR, cause highly productive infection of murine ovaries, but infection could be partially inhibited in vivo using an antiserum to asialo-GM1 (as-GM1). In vitro analysis by flow cytometry revealed that murine ovarian cells expressed a cell surface antigen identical to or cross-reactive with as-GM1. The capacity of VV-WR to infect murine ovaries appears to depend in part upon as-GM1 expression on ovarian cells.

Item Details

Item Type:Refereed Article
Keywords:Recombinant vaccinia virus; IL-2; protective immunity; NK cells; ovarian damage; anti-asialo-GM1
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142866
Year Published:1990
Web of Science® Times Cited:13
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-02
Downloads:0

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