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Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection

Citation

Karupiah, G and Blanden, RV and Ramshaw, IA, Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection, The Journal of Experimental Medicine, 172, (5) pp. 1495-503. ISSN 0022-1007 (1990) [Refereed Article]


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Copyright Statement

Copyright 1990 the authors. The Rockefeller University Press.

DOI: doi:10.1084/jem.172.5.1495

Abstract

Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb. In vitro, both asialo-GM1+ and asialo-GM1- nude mouse splenocytes produced IFN-gamma in response to IL-2.

Item Details

Item Type:Refereed Article
Keywords:Recombinant vaccinia virus; IL-2; protective immunity; IFN-g-mediated protection
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142865
Year Published:1990
Web of Science® Times Cited:114
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-05-27
Downloads:0

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