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Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection

Citation

Karupiah, G and Chen, J-H and Nathan, CF and Mahalingam, S and MacMicking, JD, Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection, Journal of Virology, 79, (2) pp. 7703-7706. ISSN 0022-538X (1998) [Refereed Article]

Copyright Statement

Copyright 1998, American Society for Microbiology

DOI: doi:10.1128/JVI.72.9.7703-7706.1998

Abstract

To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

Item Details

Item Type:Refereed Article
Keywords:Nitric oxide; antiviral immunity; ectromelia virus
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142844
Year Published:1998
Web of Science® Times Cited:48
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-31
Downloads:0

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