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Influenza virus inhibits amiloride-sensitive Na+ channels in respiratory epithelia

journal contribution
posted on 2023-05-20, 21:02 authored by Kunzelmann, K, Beesley, AH, King, NJ, Gunasegaran KarupiahGunasegaran Karupiah, Young, JA, Cook, DI
Many pathogens causing diarrhea do so by modulating ion transport in the gut. Respiratory pathogens are similarly associated with disturbances of fluid balance in the respiratory tract, although it is not known whether they too act by altering epithelial ion transport. Here we show that influenza virus AyPRy8y34 inhibits the amiloride-sensitive Na1 current across mouse tracheal epithelium with a half-time of about 60 min. We further show that the inhibitory effect of the influenza virus is caused by the binding of viral hemagglutinin to a cell-surface receptor, which then activates phospholipase C and protein kinase C. Given the importance of epithelial Na1 channels in controlling the amount of fluid in the respiratory tract, we suggest that down-regulation of Na1 channels induced by influenza virus may play a role in the fluid transport abnormalities that are associated with influenza infections.

History

Publication title

National Academy of Sciences of The United States of America. Proceedings

Volume

97

Issue

18

Pagination

10282-10287

ISSN

0027-8424

Department/School

Tasmanian School of Medicine

Publisher

Natl Acad Sciences

Place of publication

2101 Constitution Ave Nw, Washington, USA, Dc, 20418

Rights statement

Copyright 2000 the authors

Repository Status

  • Restricted

Socio-economic Objectives

Prevention of human diseases and conditions; Treatment of human diseases and conditions

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