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Expression of the interferon-inducible chemokines MuMig and Crg-2 following vaccinia virus infection in vivo

Citation

Mahalingam, S and Karupiah, G, Expression of the interferon-inducible chemokines MuMig and Crg-2 following vaccinia virus infection in vivo, Immunology and Cell Biology, 78, (2) pp. 156-160. ISSN 0818-9641 (2000) [Professional, Refereed Article]


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DOI: doi:10.1046/j.1440-1711.2000.00894.x

Abstract

MuMig (monokine induced by gamma interferon) and Crg-2 (cytokine responsive gene) are chemokines of the CXC subfamily. They share activity as T and NK cell chemoattractants. Crg-2 has been shown to be inducible by IFN, TNF, IL-1 and LPS, whereas the expression of MuMig is thought to be strictly dependent on IFN-gamma. In the present study, the kinetics of expression of the genes for MuMig and Crg-2 were analysed by northern blot analysis in organs of normal mice and in groups of gene knockout mice deficient in IFN-gamma (IFN-gamma-/-) or receptors for IFN-alpha/beta and IFN-gamma (double R-/-; DR-/-) after vaccinia virus infection. MuMig mRNA was not expressed in IFN-gamma-/- mice in all organs examined, whereas Crg-2 mRNA levels were marginally reduced. In contrast, MuMig and Crg-2 mRNA transcripts were completely abolished in the DR-/- mice.

Item Details

Item Type:Professional, Refereed Article
Keywords:IFN-g; chemokines; chemotaxis; antiviral immunity; poxviruses
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Innate immunity
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142834
Year Published:2000
Web of Science® Times Cited:8
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-03
Downloads:0

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