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Acute effects of parainfluenza virus on epithelial electrolyte transport


Kunzelmann, K and Konig, J and Sun, J and Markovich, D and King, NJ and Karupiah, G and Young, JA and Cook, DI, Acute effects of parainfluenza virus on epithelial electrolyte transport, Journal of Biological Chemistry, 279, (47) pp. 48760 -48766. ISSN 0021-9258 (2004) [Refereed Article]

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DOI: doi:10.1074/jbc.M409747200


Parainfluenza viruses are important causes of respiratory disease in both children and adults. In particular, they are the major cause of the serious childhood illness croup (laryngotracheobronchitis). The infections produced by parainfluenza viruses are associated with the accumulation of ions and fluid in the respiratory tract. It is not known, however, whether this accumulation is because of a direct effect of the viruses on ion and fluid transport by the respiratory epithelium. Here we show that a model parainfluenza virus (the Sendai virus), in concentrations observed during respiratory infections, activates Cl secretion and inhibits Na absorption across the tracheal epithelium. It does so by binding to a neuraminidase-insensitive glycolipid, possibly asialoGM1, triggering the release of ATP, which then acts in an autocrine fashion on apical P2Y receptors to produce the observed changes in ion transport. These findings indicate that fluid accumulation in the respiratory tract associated with parainfluenza virus infection is attributable, at least in part, to direct effects of the virus on ion transport by the respiratory epithelium.

Item Details

Item Type:Refereed Article
Keywords:Lung pathology; para influenza A virus; electrolyte transport; epithelial sodium channel
Research Division:Biological Sciences
Research Group:Biochemistry and cell biology
Research Field:Cellular interactions (incl. adhesion, matrix, cell wall)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142827
Year Published:2004
Web of Science® Times Cited:33
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-02-19

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