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Poxvirus CD8+ T-Cell determinants and cross-reactivity in BALB/c mice


Tscharke, DC and Woo, W-P and Sakala, IG and Sidney, J and Sette, A and Moss, DJ and Bennink, JR and Karupiah, G and Yewdell, JW, Poxvirus CD8+ T-Cell determinants and cross-reactivity in BALB/c mice, Journal of Virology, 80, (13) pp. 6318-6323. ISSN 0022-538X (2006) [Refereed Article]

Copyright Statement

Copyright 2006, American Society for Microbiology

DOI: doi:10.1128/JVI.00427-06


Mouse models of orthopoxvirus disease provide great promise for probing basic questions regarding host responses to this group of pathogens, which includes the causative agents of monkeypox and smallpox. However, some essential tools for their study that are taken for granted with other mouse models are not available for these viruses. Here we map and characterize the initial CD8+ T-cell determinants for poxviruses in H-2d-haplotype mice. CD8+ T cells recognizing these three determinants make up around 40% of the total responses to vaccinia virus during and after resolution of infection. We then use these determinants to test if predicted conservation across orthopoxvirus species matches experimental observation and find an unexpectedly cross-reactive variant peptide encoded by ectromelia (mousepox) virus.

Item Details

Item Type:Refereed Article
Keywords:Cytotoxic T lymphocytes; orthopoxvirus; CD8 T cell determinants; H-2d
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142821
Year Published:2006
Web of Science® Times Cited:87
Deposited By:Medicine
Deposited On:2021-02-12
Last Modified:2021-03-31

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