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Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models

Citation

Foster, CG and Landowski, LM and Sutherland, BA and Howells, DW, Differences in fatigue-like behavior in the lipopolysaccharide and poly I:C inflammatory animal models, Physiology and Behavior, 232 pp. 1-10. ISSN 0031-9384 (2021) [Refereed Article]


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Copyright 2021 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.1016/j.physbeh.2021.113347

Abstract

Central fatigue is a condition associated with impairment of the central nervous system often leading to the manifestation of a range of debilitating symptoms. Fatigue can be a consequence of systemic inflammation following an infection. Administration of lipopolysaccharide (LPS) and polyriboinosinic:polyribocytidlic (poly I: C) to animals can induce systemic inflammation by mimicking a bacterial or viral infection respectively and therefore have been used as models of fatigue. We evaluated a range of phenotypic behaviors exhibited in the LPS and poly I:C animal models to assess whether they adequately replicate fatigue symptomology in humans. In addition to standard observation- and intervention-based behavioral assessments, we used powerful in-cage monitoring technology to quantify rodent behavior without external interference. LPS and poly I:C treated Sprague Dawley rats displayed ‘sickness behaviors’ of elevated temperature, weight loss and reduced activity in the open field test and with in-cage monitoring within 24 h post-treatment, but only LPS-treated rats displayed these behaviors beyond these acute timepoints. Once sickness behavior diminished, LPS-treated rats exhibited an increase in reward-seeking and motivation behaviors. Overall, these results suggest that the LPS animal model produces an extensive and sustained fatigue-like phenotype, whereas the poly I:C model only produced acute effects. Our results suggest that the LPS animal model is a more suitable candidate for further studies on central fatigue-like behavior.

Item Details

Item Type:Refereed Article
Keywords:animal models, inflammation, fatigue, neuroscience, neurology, glut1, aquaporin, LPS, Poly I:C
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biomedical and clinical sciences
UTAS Author:Foster, CG (Miss Catherine Foster)
UTAS Author:Landowski, LM (Dr Lila Landowski)
UTAS Author:Sutherland, BA (Associate Professor Brad Sutherland)
UTAS Author:Howells, DW (Professor David Howells)
ID Code:142735
Year Published:2021
Deposited By:Office of the School of Medicine
Deposited On:2021-02-09
Last Modified:2021-04-28
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