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Endogenous anti-cancer candidates in GPCR, ER stress, and EMT

journal contribution
posted on 2023-05-20, 20:04 authored by Gundamaraju, R, Wenying LuWenying Lu, Iman AzimiIman Azimi, Rajaraman Eri, Sukhwinder SohalSukhwinder Sohal
The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress). Since GPCR signalling is pivotal in numerous malignancies, they are widely targeted by a number of clinical drugs. Cancer cells often negatively modulate GPCRs in order to survive, proliferate and to disseminate. Similarly, numerous branches of the unfolded protein response (UPR) act as pro-survival mediators and are involved in promoting cancer progression via mechanisms such as epithelial to mesenchymal transition (EMT). However, there are a few proteins among these groups which impede deleterious effects by orchestrating the pro-apoptotic phenomenon and paving a therapeutic pathway. The present review exposes and discusses such critical mechanisms and some of the key processes involved in carcinogenesis.

History

Publication title

Biomedicines

Volume

8

Issue

10

Article number

402

Number

402

Pagination

1-13

ISSN

2227-9059

Department/School

School of Health Sciences

Publisher

MDPI AG

Place of publication

Switzerland

Rights statement

Copyright unknown

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

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