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Brachial-cuff excess pressure is associated with carotid intima-media thickness among Australian children: a cross-sectional population study


Peng, X and Picone, DS and Schultz, MG and Cai, G and Wake, M and Burgner, DP and Mynard, JP and Ellul, S and Cheung, M and Juonala, M and Sharman, JE, Brachial-cuff excess pressure is associated with carotid intima-media thickness among Australian children: a cross-sectional population study, Hypertension Research pp. 1-9. ISSN 0916-9636 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 The Japanese Society of Hypertension

DOI: doi:10.1038/s41440-020-00576-z


Reservoir pressure parameters (i.e., reservoir pressure [RP] and excess pressure [XSP]) independently predict cardiovascular events in adults, but this has not been investigated in children. This study aimed to determine (1) the association of reservoir pressure parameters with carotid intima-media thickness (carotid IMT), a preclinical vascular phenotype, and (2) whether a multivariable regression model with or without reservoir pressure parameters fits better for estimating carotid IMT in children. Study participants were 11-12-year-old children (n = 1231, 50% male) from the Child Health CheckPoint study, a cross-sectional substudy of the population-based Longitudinal Study of Australian Children. RP and XSP were obtained using brachial-cuff oscillometry (SphygmoCor XCEL, AtCor, Sydney). Carotid IMT was quantified by vascular ultrasonography. XSP was associated with carotid IMT after adjusting for confounders including age, sex, BMI z-score, heart rate, pubertal stage, moderate-to-vigorous physical activity, and mean arterial pressure (β = 0.93 Ám, 95% CI 0.30-1.56 for XSP peak and β = 0.04 Ám, 95% CI 0.01-0.08 for XSP integral). The results of the likelihood ratio test indicated a trend that the model with XSP and the above confounders fit better than a similar model without XSP for estimating carotid IMT. Our findings indicate that brachial-cuff device-measured XSP is associated with carotid IMT independent of conventional cardiovascular risk factors, including standard BP. This implies that a clinically convenient cuff approach could provide meaningful information for the early assessment of cardiovascular risk among children.

Item Details

Item Type:Refereed Article
Keywords:atherosclerosis, blood pressure monitor, childhood, waveform analysis
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Peng, X (Miss Xiaoqing Peng)
UTAS Author:Picone, DS (Dr Dean Picone)
UTAS Author:Schultz, MG (Dr Martin Schultz)
UTAS Author:Cai, G (Mr Guoqi Cai)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:142195
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-12-22
Last Modified:2021-02-17

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