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Potential diagnostics and therapeutic approaches in COVID-19

Citation

Kumari, P and Singh, A and Ngasainao, MR and Shakeel, I and Kumar, S and Lal, S and Singhal, A and Sohal, SS and Singh, IK and MI, H, Potential diagnostics and therapeutic approaches in COVID-19, Clinica Chimica Acta, 510 pp. 488-497. ISSN 0009-8981 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Elsevier B.V.

DOI: doi:10.1016/j.cca.2020.08.013

Abstract

The most important aspect of controlling COVID-19 is its timely diagnosis. Molecular diagnostic tests target the detection of any of the following markers such as the specific region of the viral genome, certain enzyme, RNA-dependent RNA polymerase, the structural proteins such as surface spike glycoprotein, nucleocapsid protein, envelope protein, or membrane protein of SARS-CoV-2. This review highlights the underlying mechanisms, advancements, and clinical limitations for each of the diagnostic techniques authorized by the Food and Drug Administration (USA). Significance of diagnosis triaging, information on specimen collection, safety considerations while handling, transport, and storage of samples have been highlighted to make medical and research community more informed so that better clinical strategies are developed. We have discussed here the clinical manifestations and hospital outcomes along with the underlying mechanisms for several drugs administered to COVID-19 prophylaxis. In addition to favourable clinical outcomes, the challenges, and the future directions of management of COVOD-19 are highlighted. Having a comprehensive knowledge of the diagnostic approaches of SARS-CoV-2, and its pathogenesis will be of great value in designing a long-term strategy to tackle COVID-19.

Item Details

Item Type:Refereed Article
Keywords:COVID-19, SARS-CoV-2, antiviral drugs, molecular diagnosis, RT-PCR, immunochromatographic assay and drug discovery
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
ID Code:141202
Year Published:2020
Web of Science® Times Cited:12
Deposited By:Health Sciences
Deposited On:2020-10-04
Last Modified:2021-04-21
Downloads:0

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