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Variation in the pharmacokinetics of glucosamine in healthy individuals

Citation

Asthana, C and Peterson, GM and Shastri, MD and Patel, RP, Variation in the pharmacokinetics of glucosamine in healthy individuals, Rheumatology, 60, (3) pp. 1205-1209. ISSN 1462-0324 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 the authors

DOI: doi:10.1093/rheumatology/keaa418

Abstract

Objectives: Clinical trial data for the efficacy of glucosamine in OA are conflicting. Reportedly, Rotta-manufactured glucosamine products are more likely to be effective, and a possible explanation is greater bioavailability than other brands. Specifically, the aim was to compare the steady-state pharmacokinetics of Rotta- and non-Rotta-manufactured glucosamine products in healthy volunteers and examine the interindividual variability.

Methods: In a crossover design, healthy adult participants ingested 1500 mg/day of a Rotta (DONA powder sachets; imported by Mylan Health, Carole Park, QLD, Australia) and a non-Rotta (glucosamine sulphate 1500 mg one-a-day tablet; Blackmores, Warriewood, NSW, Australia) glucosamine product/brand individually for 6 days. Blood samples were collected immediately before and for 12 h after the ingestion of the last dose of each brand and analysed to determine plasma levels of glucosamine. The pharmacokinetic parameters at steady state [including the minimum (Css min) and maximum (Css max) plasma concentration of glucosamine, time to reach Css max post-dosing (Tss max) and area under the plasma concentration vs time curve (AUCss 012)] for each brand were calculated and statistically compared.

Results: Fourteen participants [mean age 35.5 years (S.D.M 8.8)] were recruited (64.2% males). No significant differences were observed in the pharmacokinetic parameters between the two brands. However, for both brands, the coefficient of variation for Css min, Tss max and AUCss 012 exceeded 20%, indicating considerable differences in the parameters between participants. No significant association of the pharmacokinetic parameters was observed with various dosing- and participant-related variables.

Conclusion: Substantial interindividual differences in the absorption and elimination of glucosamine could be a cause of variable clinical outcomes in OA.

Item Details

Item Type:Refereed Article
Keywords:pharmacokinetic, plasma, HPLC, osteoarthritis, glucosamine, pharmacokinetics, absorption, elimination, variability
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Asthana, C (Mrs Chhavi Asthana)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Shastri, MD (Mr Madhur Shastri)
UTAS Author:Patel, RP (Dr Rahul Patel)
ID Code:140826
Year Published:2020
Deposited By:Pharmacy
Deposited On:2020-09-10
Last Modified:2021-06-10
Downloads:0

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