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Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis


Lo, LMP and Taylor, BV and Winzenberg, T and Palmer, AJ and Blizzard, L and Ahmad, H and Hussain, MA and van der Mei, I, Estimating the relative contribution of comorbidities in predicting health-related quality of life of people with multiple sclerosis, Journal of Neurology, (September) pp. 1-13. ISSN 0340-5354 (2020) [Refereed Article]

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Available from 02 September 2021

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Springer-Verlag GmbH Germany, part of Springer Nature 2020. Post-prints are subject to Springer Nature re-use terms

DOI: doi:10.1007/s00415-020-10195-w


Background: Little is known about the relative contribution of comorbidities in predicting the health-related quality of life (HRQoL) of people with Multiple Sclerosis (PwMS).

Objective: To determine the associations between the number of and individual comorbidities and HRQoL and estimate the relative contribution of different comorbidities on HRQoL.

Methods: Cross-sectional analysis of data on self-reported presence of 30 comorbidities and HRQoL from the Australian MS Longitudinal Study (AMSLS) participants (n = 902). HRQoL was measured using the Assessment of Quality of Life-8 Dimensions (AQoL-8D). Linear regression and general dominance analysis were used.

Results: Higher number of comorbidities was associated with lower HRQoL (p trend p < 0.01). Comorbidities accounted for 18.1% of the variance in HRQoL. Mental health and musculoskeletal disorders were the strongest contributors to lower HRQoL. Of individual comorbidities, systemic lupus erythematosus (SLE) [β = - 0.16 (- 0.27, - 0.05)] and depression [β = - 0.15(- 0.18, - 0.13)] were most strongly associated with overall HRQoL, depression [β = - 0.14(- 0.16, - 0.11)] and anxiety [β = - 0.10 (- 0.13, - 0.07)] with psychosocial HRQoL, and SLE [β = - 0.18 (- 0.29, - 0.07)], rheumatoid arthritis [β = - 0.11 (- 0.19, - 0.02)] and hyperthyroidism [β = - 0.11 (- 0.19, - 0.03)) with physical HRQoL.

Conclusion: Comorbidities potentially make important contributions to HRQoL in PwMS. Our findings highlight groups of and individual comorbidities that could provide the largest benefits for the HRQoL of PwMS if they were targeted for prevention, early detection, and optimal treatment.

Item Details

Item Type:Refereed Article
Keywords:AQoL-8D, comorbidity, general dominance analysis, multiple sclerosis, quality of life, relative contribution
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Lo, LMP (Miss Lara Lo)
UTAS Author:Taylor, BV (Professor Bruce Taylor)
UTAS Author:Winzenberg, T (Professor Tania Winzenberg)
UTAS Author:Palmer, AJ (Professor Andrew Palmer)
UTAS Author:Blizzard, L (Professor Leigh Blizzard)
UTAS Author:Ahmad, H (Mr Hasnat Ahmad)
UTAS Author:Hussain, MA (Dr Akhtar Hussain)
UTAS Author:van der Mei, I (Professor Ingrid van der Mei)
ID Code:140820
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-09-09
Last Modified:2020-10-26

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