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Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study


Beckett, JM and Singh, NK and Phillips, J and Kalpurath, K and Taylor, K and Stanley, RA and Eri, RD, Anti-heartburn effects of sugar cane flour: A double-blind, randomized, placebo-controlled study, Nutrients, 12 pp. 1-9. ISSN 2072-6643 (2020) [Refereed Article]


Copyright Statement

Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3390/nu12061813


Gastroesophageal reflux disease (GERD) affects approximately 20% of Australians. Patients suffer a burning sensation known as heartburn due to the movement of acidic stomach content into the esophagus. There is anecdotal evidence of the effectiveness of prebiotic sugarcane flour in controlling symptoms of GERD. This pilot study aimed to investigate the effectiveness of a prebiotic sugarcane flour in alleviating symptoms in medically-diagnosed GERD patients. This pilot study was a single center, double-blinded, placebo-controlled randomized trial conducted on 43 eligible participants. The intervention group (n = 22) were randomized to receive 3 g of sugarcane flour per day, and the control group (n = 21) received 3 g of cellulose placebo per day. Symptoms of gastroesophageal reflux disease were assessed before and after three weeks treatment using the validated Gastroesophageal Reflux Disease-Health Related Quality of Life questionnaire (GERD-HRQL). After three weeks there were significant differences in symptoms for heartburn, regurgitation, and total symptoms scores (p< 0.05) between the sugarcane flour and placebo. Mean GERD-HRQL scores increased in the placebo group for regurgitation (mean increase 1.7; 95% CI 0.23 to 3.2; p = 0.015) and total symptom scores (2.9; 95% CI 0.26 to 5.7; p = 0.033). In contrast, there were significant reductions in heartburn (mean decrease −2.2; 95% CI −4.2 to −0.14; p = 0.037) and total symptom scores (−3.7; 95% CI −7.2 to −0.11; p = 0.044) in the intervention group. This pilot study has shown significant positive effects of sugarcane flour in the reduction of GERD symptoms, and a larger randomized controlled trial is warranted.

Item Details

Item Type:Refereed Article
Keywords:gastroesophageal reflux disease, heartburn, regurgitation, sugarcane flour, dietary fiber
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutrition and dietetics not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Beckett, JM (Dr Jeff Beckett)
UTAS Author:Singh, NK (Mr Neeraj Singh)
UTAS Author:Stanley, RA (Professor Roger Stanley)
UTAS Author:Eri, RD (Associate Professor Raj Eri)
ID Code:139528
Year Published:2020
Web of Science® Times Cited:1
Deposited By:Health Sciences
Deposited On:2020-06-18
Last Modified:2020-07-24
Downloads:4 View Download Statistics

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