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Type 2 diabetes mellitus is independently associated with decreased neural baroreflex sensitivity: The Paris Prospective Study III

Citation

Cseh, D and Climie, RE and Offredo, L and Guibout, C and Thomas, F and Zanoli, L and Danchin, N and Sharman, JE and Laurent, S and Jouven, X and Boutouyrie, P and Empana, J-P, Type 2 diabetes mellitus is independently associated with decreased neural baroreflex sensitivity: The Paris Prospective Study III, Arteriosclerosis, Thrombosis, and Vascular Biology, 40, (5) pp. 1420-1428. ISSN 1079-5642 (2020) [Refereed Article]


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Copyright 2020 American Heart Association, Inc.

DOI: doi:10.1161/ATVBAHA.120.314102

Abstract

Objective: Impaired baroreflex function is an early indicator of cardiovascular autonomic imbalance. Patients with type 2 diabetes mellitus (T2D) have decreased baroreflex sensitivity (BRS), however, whether the neural BRS (nBRS) and mechanical component of the BRS is altered in those with high metabolic risk (HMR, impaired fasting glucose and metabolic syndrome) or with overt T2D, is unknown. We examined this in a community-based observational study, the Paris Prospective Study III (PPS3).

Approach and Results: In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and RR [time elapsed between two successive R waves] intervals) and mechanical BRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared with subjects with normal glucose metabolism and nBRS or mechanical BRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (616 years, 77% male), 1450 subjects with HMR (606 years, 72% male), and 5857 subjects with normal glucose metabolism (596 years, 57% male). Compared with normal glucose metabolism, nBRS was significantly lower in HMR subjects (β=-0.07 [95% CI, -0.12 to -0.01]; P=0.029) and in subjects with T2D (β=-0.18 [95% CI, -0.29 to -0.07]; P=0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mechanical BRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome.

Conclusions: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with normal glucose metabolism subjects.

Item Details

Item Type:Refereed Article
Keywords:baroreflex, blood pressure, carotid sinus, diabetes mellitus, metabolic syndrome, vascular stiffness
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Climie, RE (Miss Rachel Climie)
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:139254
Year Published:2020
Web of Science® Times Cited:5
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-06-03
Last Modified:2021-03-24
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