Cseh, D and Climie, RE and Offredo, L and Guibout, C and Thomas, F and Zanoli, L and Danchin, N and Sharman, JE and Laurent, S and Jouven, X and Boutouyrie, P and Empana, J-P, Type 2 diabetes mellitus is independently associated with decreased neural baroreflex sensitivity: The Paris Prospective Study III, Arteriosclerosis, Thrombosis, and Vascular Biology, 40, (5) pp. 1420-1428. ISSN 1079-5642 (2020) [Refereed Article]
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Copyright 2020 American Heart Association, Inc.
Approach and Results: In 7626 adults aged 50 to 75 years, resting nBRS (estimated by low-frequency gain, from carotid distension rate and RR [time elapsed between two successive R waves] intervals) and mechanical BRS were measured by high-precision carotid echotracking. The associations between overt T2D or HMR as compared with subjects with normal glucose metabolism and nBRS or mechanical BRS were quantified using multivariable linear regression analysis. There were 319 subjects with T2D (61±6 years, 77% male), 1450 subjects with HMR (60±6 years, 72% male), and 5857 subjects with normal glucose metabolism (59±6 years, 57% male). Compared with normal glucose metabolism, nBRS was significantly lower in HMR subjects (β=-0.07 [95% CI, -0.12 to -0.01]; P=0.029) and in subjects with T2D (β=-0.18 [95% CI, -0.29 to -0.07]; P=0.002) after adjustment for confounding and mediating factors. Subgroup analysis suggests significant and independent alteration in mechanical BRS only among HMR patients who had both impaired fasting glucose and metabolic syndrome.
Conclusions: In this community-based study of individuals aged 50 to 75, a graded decrease in nBRS was observed in HMR subjects and patients with overt T2D as compared with normal glucose metabolism subjects.
|Item Type:||Refereed Article|
|Keywords:||baroreflex, blood pressure, carotid sinus, diabetes mellitus, metabolic syndrome, vascular stiffness|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Climie, RE (Miss Rachel Climie)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||5|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||1 View Download Statistics|
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