Huang, Z and Fonseca, R and Sharman, JE and Park, C and Chaturvedi, N and Howe, LD and Hughes, AD and Schultz, MG, The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence, Scandinavian Journal of Medicine and Science in Sports, 30, (6) pp. 1033-1039. ISSN 0905-7188 (2020) [Refereed Article]
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Methods: 4835 adolescents from the Avon Longitudinal Study of Parents and Children, (15.4 (0.3) years, 49% male) completed a submaximal cycle test. Fitness was estimated as physical work capacity 170 adjusted for lean body mass and post-exercise BP measured immediately posttest. Cardiovascular structure and function, including left ventricular (LV) mass (n = 1589), left atrium (LA) size (n = 1466), cardiac output (CO, n = 1610), and total peripheral resistance (TPR, n = 1610) were measured at rest by echocardiography 2.4 (0.4) years later.
Results: Post-exercise systolic BP increased stepwise by fitness tertile (131.2 mm Hg [130.4, 132.1]; 137.3 mm Hg [136.5, 138.0]; 142.3 mm Hg [141.5, 143.1]). Each 5 mm Hg of post-exercise systolic BP was associated with 2.46 g [1.91, 3.01] greater LV mass, 0.02 cm [0.02, 0.03] greater LA size, and 0.25 g/m2.7 [0.14, 0.36] greater LV mass index. Adjustment for fitness abolished associations (0.29 g [-0.16, 0.74]; 0.01 cm [-0.001, 0.014] and 0.08 g/m2.7 [-0.001, 0.002]). Similar associations between post-exercise systolic BP and each outcome were found between the lowest and highest fitness thirds. CO increased with fitness third (difference 0.06 L/min [-0.05, 0.17]; 0.23 L/min [0.12, 0.34]) while TPR decreased (difference -0.13 mm Hg·min/L [-0.84,0.59]; -1.08 mm Hg·min/L [-0.1.80, 0.35]).
Conclusions: Post-exercise systolic BP increased with fitness, which modified its association with cardiac structure. Higher CO, but lower TPR suggests a physiologically adapted cardiovascular system with greater fitness, highlighting the importance of fitness in adolescence.
|Item Type:||Refereed Article|
|Keywords:||adolescent, ALSPAC, blood pressure, exercise, fitness, left ventricle|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Huang, Z (Mr Zhiqiang Huang)|
|UTAS Author:||Fonseca, R (Mr Ricardo Fonseca Diaz)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|UTAS Author:||Schultz, MG (Dr Martin Schultz)|
|Web of Science® Times Cited:||3|
|Deposited By:||Menzies Institute for Medical Research|
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