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Neural remodelling in spiny lobster larvae is characterized by broad neuropeptide suppression

Citation

Hyde, CJ and Nguyen, T and Fitzgibbon, QP and Elizur, A and Smith, GG and Ventura, T, Neural remodelling in spiny lobster larvae is characterized by broad neuropeptide suppression, General and Comparative Endocrinology, 294 Article 113496. ISSN 0016-6480 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Elsevier Inc.

DOI: doi:10.1016/j.ygcen.2020.113496

Abstract

Neuropeptides are ancient endocrine components which have evolved to regulate many aspects of biology across the animal kingdom including behaviour, development and metabolism. To supplement current knowledge, we have utilized a transcriptome series describing larval development in the ornate spiny lobster, Panulirus ornatus. The biology of this animal has been leveraged to provide insights into the roles of molting, metamorphosis and metabolism across the neuropeptide family. We report an extensive list of neuropeptides across three distinct life phases of the animal. We show distinct groups of neuropeptides with differential expression between larval phases, indicating phase-specific roles for these peptides. For selected neuropeptides, we describe and discuss expression profiles throughout larval development and report predicted peptide cleavage sites and mature peptide sequences. We also report the neuropeptide nesfatin for the first time in a crustacean, and report secondary peptide products with a level of evolutionary conservation similar to the conventional mature peptide nesfatin-1, indicating a conserved role in these secondary products which are widely regarded as biologically inactive. In addition, we report a trend of downregulation in the neuropeptides as the animal undergoes extensive neural remodelling in fulfillment of metamorphosis. We suggest that this downregulation in neuropeptides relates to the brief, yet dramatic changes in morphology experienced by the central nervous system in the process of metamorphosis.

Item Details

Item Type:Refereed Article
Keywords:Phyllosoma, neural remodelling, metamorphosis, Panulirus ornatus, crustacean, transcriptome, brain, regulation, molt
Research Division:Agricultural, Veterinary and Food Sciences
Research Group:Fisheries sciences
Research Field:Aquaculture
Objective Division:Animal Production and Animal Primary Products
Objective Group:Fisheries - aquaculture
Objective Field:Aquaculture rock lobster
UTAS Author:Fitzgibbon, QP (Associate Professor Quinn Fitzgibbon)
UTAS Author:Smith, GG (Professor Gregory Smith)
ID Code:138880
Year Published:2020
Funding Support:Australian Research Council (IH120100032)
Deposited By:Fisheries and Aquaculture
Deposited On:2020-05-07
Last Modified:2020-12-08
Downloads:0

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