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The association of subchondral and systemic bone mineral density with osteoarthritis-related joint replacements in older adults

Citation

Cai, G and Otahal, P and Cicuttini, F and Wu, F and Munugoda, IP and Jones, G and Aitken, D, The association of subchondral and systemic bone mineral density with osteoarthritis-related joint replacements in older adults, Osteoarthritis and Cartilage, 28, (4) pp. 438-445. ISSN 1063-4584 (2020) [Refereed Article]

Copyright Statement

Copyright 2020 Osteoarthritis Research Society International

DOI: doi:10.1016/j.joca.2020.02.832

Abstract

Objective: To describe the association of subchondral and systemic bone mineral density (BMD) with knee and hip replacements (KR and HR, respectively) due to osteoarthritis.

Design: 1,095 participants (mean age 63 years, 51% female) were included. At baseline, subchondral BMD of the medial and lateral tibia in three regions of interest (ROI) for the right knee, and systemic BMD of the lumbar spine, femoral neck, total hip and whole-body, were measured using dual-energy X-ray absorptiometry. Subchondral BMD of the hip was not measured. Competing risk regression models were used to estimate sub-distribution hazard ratios (SHRs) of KR/HR per one standard deviation (SD) higher in BMD measures, with adjustment of potential confounders.

Results: Over 12.2 years, 79 (7.2%) participants underwent a KR and 56 (5.1%) an HR due to osteoarthritis. For the right side, medial subchondral BMD in ROI-3 was associated with an increased risk of KR (SHR 1.95 per SD; 95% Confidence Interval [CI], 1.57 to 2.43). In contrast, systemic BMD was not associated with the risk of KR, but higher BMD at the lumbar spine (1.42, 1.07 to 1.88) and whole-body (1.29, 1.00 to 1.66) were associated with an increased risk of HR at both sides.

Conclusions: Subchondral BMD is positively associated with an increased risk of KR and systemic BMD with an increased risk of HR, suggesting a role of BMD in the progression of osteoarthritis.

Item Details

Item Type:Refereed Article
Keywords:bone mineral density, hip replacement, knee replacement, osteoarthritis
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Cai, G (Mr Guoqi Cai)
UTAS Author:Otahal, P (Mr Petr Otahal)
UTAS Author:Wu, F (Dr Feitong Wu)
UTAS Author:Munugoda, IP (Mr Ishanka Munugoda)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Aitken, D (Associate Professor Dawn Aitken)
ID Code:138798
Year Published:2020
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-04-30
Last Modified:2021-03-23
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