Armstrong, MK and Schultz, MG and Picone, DS and Black, JA and Dwyer, N and Roberts-Thomson, P and Sharman, JE, Associations of reservoir-excess pressure parameters derived from central and peripheral arteries with kidney function, American Journal of Hypertension, 33, (4) pp. 325-330. ISSN 0895-7061 (2020) [Refereed Article]
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Copyright 2020 American Journal of Hypertension, Ltd.
Methods: Intra-arterial blood pressure (BP) waveforms were measured sequentially at the aorta, brachial, and radial arteries among 220 individuals (aged 61 ± 10 years, 68% male). Customized software was used to derive reservoir-excess pressure parameters at each arterial site (reservoir and excess pressure, systolic and diastolic rate constants) and clinical relevance was determined by association with estimated glomerular filtration rate (eGFR).
Results: Between the aorta and brachial artery, the mean difference in the diastolic rate constant and reservoir pressure integral was -0.162 S-1 (P = 0.08) and -0.772 mm Hg s (P = 0.23), respectively. The diastolic rate constant had the strongest and most consistent associations with eGFR across aortic and brachial sites (β = -0.20, P = 0.02; β = -0.20, P = 0.03, respectively; adjusted for traditional cardiovascular risk factors). Aortic, but not brachial peak reservoir pressure was associated with eGFR in adjusted models (aortic β = -0.48, P = 0.02).
Conclusions: The diastolic rate constant is the most consistent reservoir-excess pressure parameter, in both its absolute values and associations with kidney dysfunction, when derived from the aorta and brachial artery. Thus, the diastolic rate constant could be utilized in the clinical setting to improve BP risk stratification.
|Item Type:||Refereed Article|
|Keywords:||blood pressure, hemodynamics, hypertension, physiology, vascular stiffness|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Armstrong, MK (Mr Matthew Armstrong)|
|UTAS Author:||Schultz, MG (Dr Martin Schultz)|
|UTAS Author:||Picone, DS (Dr Dean Picone)|
|UTAS Author:||Black, JA (Dr Andrew Black)|
|UTAS Author:||Sharman, JE (Professor James Sharman)|
|Web of Science® Times Cited:||3|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||1 View Download Statistics|
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