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Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis

Citation

Park, J-S and Shim, Y-J and Kang, BH and Lee, W-K and Min, B-H, Hepatocyte-specific clusterin overexpression attenuates diet-induced nonalcoholic steatohepatitis, Biochemical and Biophysical Research Communications, 495, (2) pp. 1775-1781. ISSN 0006-291X (2017) [Refereed Article]

Copyright Statement

2017 Elsevier Inc. All rights reserved.

DOI: doi:10.1016/j.bbrc.2017.12.045

Abstract

Clusterin is a multifunctional glycoprotein that plays important roles and is up-regulated in liver diseases such as hepatitis and hepatocellular carcinoma. However, little is known about the significance of clusterin in the pathogenesis of non-alcoholic steatohepatitis (NASH). The aim of this study is to examine the role of clusterin in progression of steatohepatitis in mice fed a methionine and choline deficient (MCD) diet. We generated hepatocyte-specific clusterin overexpression (hCLU-tg) mice, and hCLU-tg mice showed lower levels of hepatic triglycerides, less infiltration of macrophages and reduction of TNF-α, activation of Nrf-2 than wild-type littermates fed the MCD diet. Also, sustained clusterin expression in liver ameliorated hepatic fibrogenesis by reducing the activation of hepatic stellate cells by MCD diet. Sustained expression of clusterin in liver functioned as a preconditioning stimulus and prevented MCD diet-induced severe steatohepatitis injury via Nrf2 activation. These results demonstrate a novel function of clusterin as an immune preconditioning regulator in various inflammatory diseases including steatohepatitis.

Item Details

Item Type:Refereed Article
Keywords:clusterin (CLU), nonalcoholic steatohepatitis (NASH), nuclear factor kappa B (NF-B), toll-like receptor 4 (TLR4), oxidative stress
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Health informatics and information systems
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Kang, BH (Professor Byeong Kang)
ID Code:137904
Year Published:2017
Web of Science® Times Cited:13
Deposited By:Information and Communication Technology
Deposited On:2020-03-12
Last Modified:2020-06-24
Downloads:0

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