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Medication adherence, burden and health-related quality of life in adults with predialysis chronic kidney disease: A prospective cohort study

Citation

Tesfaye, WH and McKercher, C and Peterson, GM and Castelino, RL and Jose, M and Zaidi, STR and Wimmer, BC, Medication adherence, burden and health-related quality of life in adults with predialysis chronic kidney disease: A prospective cohort study, International Journal of Environmental Research and Public Health, 17, (1) Article 371. ISSN 1660-4601 (2020) [Refereed Article]


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Copyright 2020 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

DOI: doi:10.3390/ijerph17010371

Abstract

This study examines the associations between medication adherence and burden, and health-related quality of life (HRQOL) in predialysis chronic kidney disease (CKD). A prospective study targeting adults with advanced CKD (estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m2) and not receiving renal replacement therapy was conducted in Tasmania, Australia. The actual medication burden was assessed using the 65-item Medication Regimen Complexity Index, whereas perceived burden was self-reported using a brief validated questionnaire. Medication adherence was assessed using a four-item Morisky-Green-Levine Scale (MGLS) and the Tool for Adherence Behaviour Screening (TABS). The Kidney Disease and Quality of Life Short-Form was used to assess HRQOL. Of 464 eligible adults, 101 participated in the baseline interview and 63 completed a follow-up interview at around 14 months. Participants were predominantly men (67%), with a mean age of 72 (SD 11) years and eGFR of 21 (SD 6) mL/min/1.73 m2. Overall, 43% and 60% of participants reported medication nonadherence based on MGLS and TABS, respectively. Higher perceived medication burden and desire for decision-making were associated with nonadherent behaviour. Poorer HRQOL was associated with higher regimen complexity, whereas nonadherence was associated with a decline in physical HRQOL over time. Medication nonadherence, driven by perceived medication burden, was prevalent in this cohort, and was associated with a decline in physical HRQOL over time.

Item Details

Item Type:Refereed Article
Keywords:chronic kidney disease, medication adherence, health-related quality of life, medication regimen complexity index, medication burden
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Nephrology and urology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Tesfaye, WH (Mr Wubshet Tesfaye)
UTAS Author:McKercher, C (Dr Charlotte McKercher)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Castelino, RL (Dr Ronald Castelino)
UTAS Author:Jose, M (Professor Matthew Jose)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
UTAS Author:Wimmer, BC (Dr Barbara Wimmer)
ID Code:137836
Year Published:2020
Web of Science® Times Cited:4
Deposited By:Pharmacy
Deposited On:2020-03-05
Last Modified:2020-04-09
Downloads:6 View Download Statistics

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