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Identification of the side products that diminish the yields of the monoamidated product in metal-catalyzed C−H amidation of 2‑phenylpyridine with arylisocyanates

Citation

McKay, AI and Altalhi, WAO and McInnes, LE and Czyz, ML and Canty, AJ and Donnelly, PS and O'Hair, RAJ, Identification of the side products that diminish the yields of the monoamidated product in metal-catalyzed C−H amidation of 2‑phenylpyridine with arylisocyanates, The Journal of Organic Chemistry, 85 pp. 2680−2687. ISSN 0022-3263 (2020) [Refereed Article]

Copyright Statement

© 2020 American Chemical Society

Abstract

The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C–H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatography–mass spectrometry.

Item Details

Item Type:Refereed Article
Keywords:catalysis, ruthenium catalysis, organic synthesis, amidation, DFT, mass spectrometry
Research Division:Chemical Sciences
Research Group:Inorganic chemistry
Research Field:Transition metal chemistry
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Canty, AJ (Professor Allan Canty)
ID Code:137680
Year Published:2020
Deposited By:Chemistry
Deposited On:2020-02-27
Last Modified:2020-04-02
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