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Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population

Citation

Ruan, J and He, X-J and Du, W-D and Chen, G and Zhou, Y and Xu, S and Zuo, X-B and Fang, L-B and Cao, Y-X and Zhang, X-J, Genetic variants in TEX15 gene conferred susceptibility to spermatogenic failure in the Chinese Han population, Reproductive Sciences, 19, (11) pp. 1190-1196. ISSN 1933-7191 (2012) [Refereed Article]

Copyright Statement

Copyright 2012 The Authors

DOI: doi:10.1177/1933719112446076

Abstract

This study aimed to analyze the distribution of single-nucleotide polymorphisms (SNPs) of testis-expressed 15 (TEX15) gene in the Chinese Han infertile men and fertile men. This case-control study comprised 309 infertile men with nonobstructive azoospermia (NOA, n = 199) or severe oligozoospermia (SO, n = 110) and 377 fertile controls. Six SNPs were genotyped by Sequenom iplex technology. The results showed that the variants rs323346 and rs323347 contributed to the increasing risk of SO (P = .041, odds ratio [OR] = 1.635, 95% confidence interval [CI] = 1.018-2.628 and P = .046, OR = 1.616, 95% CI = 1.006-2.597). The haplotype AT of the SNPs rs323347 and rs323346 could reduce risk in the patients with SO (P = .040, OR = 0.616, and 95% CI = 0.383-0.990). The haplotype GC of the variants rs323347 and rs323346 conferred a significantly increased risk of SO (P = .040, OR = 1.624, 95% CI = 1.010-2.610). Thus, the polymorphisms rs323346 and rs323347 of the TEX15 gene could be considered the genetic risk factors for spermatogenic failure in the Chinese Han population.

Item Details

Item Type:Refereed Article
Keywords:genetics, spermatogenic failure, male infertility, TEX15 gene, SNPs, spermatogenesis
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Genomics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhou, Y (Mr Yuan Zhou)
ID Code:136949
Year Published:2012
Web of Science® Times Cited:16
Deposited By:Menzies Institute for Medical Research
Deposited On:2020-01-23
Last Modified:2020-05-28
Downloads:0

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