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Anaesthetists' drug dosing practices in class III obese surgical patients: A bi-national survey


Hussain, Z and Gadd, K and Curtain, C and Mirkazemi, C and Peterson, GM and Zaidi, STR, Anaesthetists' drug dosing practices in class III obese surgical patients: A bi-national survey, Anaesthesia and Intensive Care pp. 1-6. ISSN 0310-057X (2019) [Refereed Article]

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Copyright The Author(s) 2019

DOI: doi:10.1177/0310057X19886596


Class III obese (body mass index  40 kg/m2 ) patients, now regularly encountered clinically, have increased perioperative risks, including potentially from suboptimal drug dosing. However, current dosing guidelines are based on low-level evidence and may not be widely accepted. This study aimed to investigate anaesthetists’ dosing practices for class III obese surgical patients, explore if they had experienced an increased incidence of adverse events potentially related to drug dosing with these patients and assess which resources they consulted for dosing advice in this population. An electronic survey was emailed to 1000 randomly selected members of the Australian and New Zealand College of Anaesthetists. Data were summarised and the Pearson’s χ2 test was used to compare respondents’ genders, geographic locations and seniority designations with the greater Australian and New Zealand College of Anaesthetists’ membership. There were 230 completed responses (response rate 23%). A large proportion (46%–76%) of respondents indicated they dose class III obese patients in keeping with current recommendations; however, substantial heterogeneity in dosing practices was found. Lean body weight was the most frequently used regimen for dosing propofol, non-depolarising muscle relaxants, sugammadex and opioids, whereas total body weight was most frequently used for suxamethonium. Nearly 70% of respondents reported using at least one resource to assist their dosing practices in obesity. Importantly, increased incidences of adverse events in class III obese patients related to drug dosing were commonly experienced by respondents. Until higher-level evidence is available for dosing class III obese patients, anaesthetists should consider current recommendations and exercise increased attention to dosing. Further clinician education may assist in optimising dosing in this patient group.

Item Details

Item Type:Refereed Article
Keywords:Anaesthetists, adverse events, class III obesity, drug dosing, dosing resources, survey
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Clinical health
Objective Field:Treatment of human diseases and conditions
UTAS Author:Hussain, Z (Mr Zahid Hussain)
UTAS Author:Curtain, C (Mr Colin Curtain)
UTAS Author:Mirkazemi, C (Mrs Corinne Mirkazemi)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Zaidi, STR (Dr Tabish Razi Zaidi)
ID Code:135982
Year Published:2019
Deposited By:Pharmacy
Deposited On:2019-11-23
Last Modified:2020-02-27

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