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Dietary fiber and its associations with depression and inflammation


Swann, OG and Kilpatrick, M and Breslin, M and Oddy, WH, Dietary fiber and its associations with depression and inflammation, Nutrition Reviews pp. 1-18. ISSN 0029-6643 (2019) [Refereed Article]

Copyright Statement

Copyright The Author(s) 2019.

DOI: doi:10.1093/nutrit/nuz072


Dietary fiber is a crucial component of a healthy diet, with benefits that can be attributed to processes in the gut microbiota and the resulting by-products. Observational studies support associations between dietary fiber intake and depression and inflammation, but the potential mechanisms are poorly understood. This review examines evidence of the effects of dietary fiber on depression and inflammation and considers plausible mechanisms linking dietary fiber and depression, including microbiota-driven modification of gene expression and increased production of neurotransmitters. Additionally, inflammation may mediate the relationship between dietary fiber intake and depression. A high-fiber diet potentially lowers inflammation by modifying both the pH and the permeability of the gut. The resultant reduction in inflammatory compounds may alter neurotransmitter concentrations to reduce symptoms of depression. Further research into the link between dietary fiber intake and inflammation and depression is essential, as findings could potentially provide guidance for improvement in or prevention of inflammatory and depressive disorders.

Item Details

Item Type:Refereed Article
Keywords:gut, depression, dietary fiber, inflammation, mental health, microbiota
Research Division:Biomedical and Clinical Sciences
Research Group:Nutrition and dietetics
Research Field:Nutritional science
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Nutrition
UTAS Author:Swann, OG (Ms Olivia Swann)
UTAS Author:Kilpatrick, M (Dr Michelle Kilpatrick)
UTAS Author:Breslin, M (Dr Monique Breslin)
UTAS Author:Oddy, WH (Professor Wendy Oddy)
ID Code:135967
Year Published:2019
Web of Science® Times Cited:34
Deposited By:Menzies Institute for Medical Research
Deposited On:2019-11-22
Last Modified:2019-12-12

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