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Nickel(IV)-Catalyzed C–H Trifluoromethylation of (Hetero)arenes
journal contribution
posted on 2023-05-20, 06:50 authored by Meucci, EA, Nguyen, SN, Camasso, NM, Chong, E, Alireza AriafardAlireza Ariafard, Allan CantyAllan Canty, Sanford, MSThis Article describes the development of a stable NiIV complex that mediates C(sp2)–H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a NiIV-catalyzed C–H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving NiIV, NiIII, and NiII intermediates.
History
Publication title
Journal of the American Chemical SocietyVolume
141Issue
32Pagination
12872−12879ISSN
0002-7863Department/School
School of Natural SciencesPublisher
ACSPlace of publication
Washington, USARights statement
© 2019 American Chemical SocietyRepository Status
- Restricted