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United colours of chromatin? Developmental genome organisation in flies

journal contribution
posted on 2023-05-20, 06:43 authored by Caroline DelandreCaroline Delandre, Owen MarshallOwen Marshall
The organisation of DNA into differing forms of packaging, or chromatin, controls many of the cell fate decisions during development. Although early studies focused on individual forms of chromatin, in the last decade more holistic studies have attempted to determine a complete picture of the different forms of chromatin present within a cell. In the fruit fly, Drosophila melanogaster, the study of chromatin states has been aided by the use of complementary and cell-type-specific techniques that profile the marks that recruit chromatin protein binding or the proteins themselves. Although many questions remain unanswered, a clearer picture of how different chromatin states affect development is now emerging, with more unusual chromatin states such as Black chromatin playing key roles. Here, we discuss recent findings regarding chromatin biology in flies.

Funding

National Health & Medical Research Council

History

Publication title

Biochemical Society Transactions

Volume

47

Pagination

691-700

ISSN

0300-5127

Department/School

Menzies Institute for Medical Research

Publisher

Portland Press

Place of publication

59 Portland Place, London, England, W1N 3Aj

Rights statement

© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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    University Of Tasmania

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