Sueud, T and Hadi, NR and Abdulameer, R and Jamil, DA and Al-Aubaidy, HA, Assessing urinary levels of IL-18, NGAL and albumin creatinine ratio in patients with diabetic nephropathy, Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 13, (1) pp. 564-568. ISSN 1871-4021 (2019) [Refereed Article]
© 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Official URL: https://www.sciencedirect.com/science/article/pii/...
Aims: Diabetic nephropathy (DN) is a serious microvascular complication of a longstanding hyperglycemia. This study aims to evaluate whether urinary neutrophil gelatinase-associated lipocalin (NGAL) and urinary Interleukin-18 possess a better diagnostic value than albumin creatinine ratio in assessing the severity of nephropathy in patients with type 2 diabetes mellitus (T2DM).
Material & methods: Ninety participants diagnosed with T2DM were recruited and they were divided into three study groups according to their albumin/creatinine ratio (ACR): (Normoalbuminuria group, Microalbuminuria group, and Macroalbuminuria group). A matching of Ninety healthy subjects were included as controls. Blood and urine samples were collected to measure various markers of glycemic control and kidney function.
Results: IL-18 levels were not changed significantly between all study groups (P > 0.05), despite a significant positive correlation between IL-18 and urinary albumin levels. NGAL levels were significantly increased in Microalbuminuria group and Macroalbuminuria group as compared to the control and Normoalbuminuria groups. NGAL was also positively correlated with urinary albumin and ACR, but negatively correlated with the age and body mass index. Receiver Operating Characteristic curves revealed that for early detection of DN, the best cutoff values to discriminate DN and diabetic without nephropathy groups were ˃ 21.4 ng/ml for NGAL (94.67 sensitivity, 26.67% specificity), ≤0.34 pg/mL for IL-18 (72% sensitivity, 53.33% specificity), and ˃29.8 mg/g for ACR (80% sensitivity, 100% specificity).
Conclusion: We conclude that the urinary ACR is a more accurate individual biomarker of DN when compared to both NGAL and IL-18.
|Item Type:||Refereed Article|
|Keywords:||albumin creatinine ration, diabetic nephropathy, Interlukin-18; neutrophil gelatinase-associated lipocalin; Type 2 diabetes|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Jamil, DA (Dr Dina Jamil)|
|UTAS Author:||Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)|
|Year Published:||2019 (online first 2018)|
|Web of Science® Times Cited:||12|
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