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Dual gold‐catalyzed cycloaromatization of unconjugated (E)‐enediynes

journal contribution
posted on 2023-05-20, 06:19 authored by Zamani, F, Rasool Babaahmadi, Brian YatesBrian Yates, Michael GardinerMichael Gardiner, Alireza AriafardAlireza Ariafard, Pyne, SG, Hyland, CJT
A synthesis of unconjugated (E)‐enediynes from allenyl amino alcohols is reported and their gold‐catalyzed cascade cycloaromatization to a broad range of enantioenriched substituted isoindolinones has been developed. Experimental and computational studies support the reaction proceeding via a dual‐gold σ,π‐activation mode, involving a key gold‐vinylidene‐ and allenyl‐gold‐containing intermediate.

Funding

Australian Research Council

University of Wollongong

History

Publication title

Angewandte Chemie

Volume

58

Issue

7

Pagination

2114 -2119

ISSN

0044-8249

Department/School

School of Natural Sciences

Publisher

Wiley

Place of publication

Germany

Rights statement

Copyright 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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