Hussain, S and Singh, A and Zameer, S and Jamali, MC and Baxi, H and Rahman, SO and Alam, M and Altamish, M and Singh, AK and Anil, D and Hussain, MS and Ahmad, A and Najmi, AK, No association between proton pump inhibitors use and risk of dementia: evidence from a meta-analysis, Journal of Gastroenterology and Hepatology pp. 1-24. ISSN 0815-9319 (2019) [Refereed Article]
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Methods: An extensive literature search was performed in PubMed, Embase, and Cochrane till 31st March 2019. All the studies (cohort, case-control) assessing the association between PPI use and dementia risk was eligible for inclusion. Articles were selected based on the screening of title and abstract, data were extracted and risk of bias was assessed using Newcastle-Ottawa Scale. The primary outcome was pooled risk of dementia among PPI user as compared to non-PPI user. Secondary outcomes include dementia risk based on subgroups. Statistical analysis was performed using Review Manager software.
Results: Twelve studies (eight cohort and four case-control) were found to be eligible for inclusion. Majority of the studies were of high quality. Dementia was diagnosed based on ICD-9/10 codes in majority of the included studies. PPI use was not associated with the dementia risk, with a pooled relative risk (RR) of 1.05 (95% CI: 0.96 - 1.15), p = 0.31. Subgroup analysis based on study design [Cohort: p = 0.14; Case control: p = 0.14], sex [RR 1.25 (95% CI: 0.97 - 1.60), p = 0.08)], H2RA blockers (p = 0.93) and for Alzheimer's disease (AD) [RR 1.00 (95% CI: 0.91 - 1.09), p = 0.93)] revealed no significant association between PPI use and dementia risk.
Conclusion: We found no significant association between PPI use and the risk of dementia or AD.
|Item Type:||Refereed Article|
|Keywords:||alzheimer's disease, dementia, meta-analysis, omeprazole, PPI|
|Research Division:||Biomedical and Clinical Sciences|
|Research Field:||Neurology and neuromuscular diseases|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Singh, A (Mr Ambrish Singh)|
|Web of Science® Times Cited:||21|
|Deposited By:||Menzies Institute for Medical Research|
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