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No association between proton pump inhibitors use and risk of dementia: evidence from a meta-analysis
Methods: An extensive literature search was performed in PubMed, Embase, and Cochrane till 31st March 2019. All the studies (cohort, case-control) assessing the association between PPI use and dementia risk was eligible for inclusion. Articles were selected based on the screening of title and abstract, data were extracted and risk of bias was assessed using Newcastle-Ottawa Scale. The primary outcome was pooled risk of dementia among PPI user as compared to non-PPI user. Secondary outcomes include dementia risk based on subgroups. Statistical analysis was performed using Review Manager software.
Results: Twelve studies (eight cohort and four case-control) were found to be eligible for inclusion. Majority of the studies were of high quality. Dementia was diagnosed based on ICD-9/10 codes in majority of the included studies. PPI use was not associated with the dementia risk, with a pooled relative risk (RR) of 1.05 (95% CI: 0.96 - 1.15), p = 0.31. Subgroup analysis based on study design [Cohort: p = 0.14; Case control: p = 0.14], sex [RR 1.25 (95% CI: 0.97 - 1.60), p = 0.08)], H2RA blockers (p = 0.93) and for Alzheimer's disease (AD) [RR 1.00 (95% CI: 0.91 - 1.09), p = 0.93)] revealed no significant association between PPI use and dementia risk.
Conclusion: We found no significant association between PPI use and the risk of dementia or AD.
History
Publication title
Journal of Gastroenterology and HepatologyVolume
35Pagination
19-28ISSN
0815-9319Department/School
Menzies Institute for Medical ResearchPublisher
Blackwell Publishing AsiaPlace of publication
54 University St, P O Box 378, Carlton, Australia, Victoria, 3053Rights statement
This article is protected by copyright. All rights reserved.Repository Status
- Restricted