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Olfaction in Drosophila: Coding, genetics and e-genetics

Citation

Warr, C and Clyne, P and De Bruyne, M and Kim, J and Carlson, JR, Olfaction in Drosophila: Coding, genetics and e-genetics, Chemical Senses, 26, (2) pp. 201-206. ISSN 0379-864X (2001) [Refereed Article]

DOI: doi:10.1093/chemse/26.2.201

Abstract

Odor coding in Drosophila is examined at both the cellular and molecular levels. Functional analysis of individual olfactory receptor neurons (ORNs) by single-unit electrophysiology has shown that ORNs divide into discrete classes, with each class exhibiting a characteristic odor response spectrum. Extensive analysis of ORNs in the maxillary palp has revealed six such classes, which are combined in sensilla according to a strict pairing rule. In order to identify the odor receptor genes that determine the odor specificity of these ORN classes, a new algorithm was designed to search DNA databases for proteins with a particular structure, as opposed to a particular sequence. The algorithm identified a large family of genes likely to encode odor receptors. The acj6 gene, originally identified in a screen for mutants defective in olfactory behavior, encodes a transcription factor that regulates a subset of these receptor genes, and is likely to play a critical role in the process by which ORNs select which receptors to express.

Item Details

Item Type:Refereed Article
Keywords:DNA; protein; transcription factor; algorithm; article; cell specificity; classification; controlled study; data base; DNA sequence; Drosophila; electrophysiology; gene expression; genetic code; genetic regulation; multigene family; nerve cell; odor
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Neurogenetics
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the biological sciences
UTAS Author:Warr, C (Professor Coral Warr)
ID Code:131986
Year Published:2001
Web of Science® Times Cited:14
Deposited By:Office of the School of Medicine
Deposited On:2019-04-16
Last Modified:2019-04-16
Downloads:0

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