Zhao, B and Johnston, FH and Dalton, M and Negishi, K, Feasibility and normal ranges of arterial intima-media thickness and stiffness in 2-year-old children: a pilot study, Pediatric Cardiology, 40, (5) pp. 914-920. ISSN 0172-0643 (2019) [Refereed Article]
Copyright 2019 Springer Science+Business Media, LLC, part of Springer Nature
Methods: Carotid intima-media thickness (cIMT) and abdominal aorta IMT (aaIMT), pulse wave velocity (PWV), arterial diameter change, stiffness index (β), and distensibility were assessed in 2-year-old children. IMT was assessed using an automatic contour detection.
Results: The proportion of successful measurements was 72% (42/58) with cIMT 64%, aaIMT 67%, and PWV 43%. Average far wall cIMT was 0.51 mm and 0.40 for aaIMT. Mean PWV was 4.15 m/s, with relatively wider range in stiffness index and distensibility. Common carotid arteries had a higher mean distensibility of 4.58%/10 mmHg compared with 2.98%/10 mmHg for the abdominal aorta. The number of data points automatically detected at far wall cIMT was higher than that in aaIMT (left cIMT: 244 ± 13 and right: 240 ± 23 vs. abdominal 185 ± 63, p < 0.001). Better and more consistent quality was achieved for cIMT than aaIMT measurements. PWV measurement was only feasible in cooperative children with efficient distractions.
Conclusions: Noninvasive methods for early detection of cardiovascular risks were feasible in at least two-thirds of 2-year-old children. Given the greater feasibility and image quality, cIMT is a preferable option for assessing vascular health in young children.
|Item Type:||Refereed Article|
|Keywords:||arterial stiffness, children, intima-media thickness, pulse wave velocity|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Zhao, B (Miss Bing Zhao)|
|UTAS Author:||Johnston, FH (Associate Professor Fay Johnston)|
|UTAS Author:||Dalton, M (Ms Marita Dalton)|
|UTAS Author:||Negishi, K (Dr Kazuaki Negishi)|
|Web of Science® Times Cited:||9|
|Deposited By:||Menzies Institute for Medical Research|
Repository Staff Only: item control page