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Dual function of thalamic low-vigilance state oscillations: rhythm-regulation and plasticity

journal contribution
posted on 2023-05-20, 02:06 authored by Crunelli, V, Lorincz, ML, William ConnellyWilliam Connelly, David, F, Hughes, SW, Lambert, RC, Leresche, N, Errington, AC
During inattentive wakefulness and non-rapid eye movement (NREM) sleep, the neocortex and thalamus cooperatively engage in rhythmic activities that are exquisitely reflected in the electroencephalogram as distinctive rhythms spanning a range of frequencies from <1 Hz slow waves to 13 Hz alpha waves. In the thalamus, these diverse activities emerge through the interaction of cell-intrinsic mechanisms and local and long-range synaptic inputs. One crucial feature, however, unifies thalamic oscillations of different frequencies: repetitive burst firing driven by voltage-dependent Ca2+ spikes. Recent evidence reveals that thalamic Ca2+ spikes are inextricably linked to global somatodendritic Ca2+ transients and are essential for several forms of thalamic plasticity. Thus, we propose herein that alongside their rhythm-regulation function, thalamic oscillations of low-vigilance states have a plasticity function that, through modifications of synaptic strength and cellular excitability in local neuronal assemblies, can shape ongoing oscillations during inattention and NREM sleep and may potentially reconfigure thalamic networks for faithful information processing during attentive wakefulness.

History

Publication title

Nature reviews. Neuroscience

Volume

19

Pagination

107-118

ISSN

1471-003X

Department/School

Tasmanian School of Medicine

Publisher

Nature Pub. Group

Place of publication

United Kingdom

Rights statement

Copyright 2017 Macmillan Publishers Limited, part of Springer Nature

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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