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Regulation and sensing of inflammasomes and their impact on intestinal health


Ranson, N and Kunde, D and Eri, R, Regulation and sensing of inflammasomes and their impact on intestinal health, International Journal of Molecular Sciences, 18, (11) pp. 1-19. ISSN 1661-6596 (2018) [Substantial Review]

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© 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0)

DOI: doi:10.3390/ijms18112379


Pattern recognition receptors such as nucleotide-binding oligomerization domain (NOD)-containing protein receptors (NLRs) and the pyrin and hematopoitic interferon-inducible nuclear protein (HIN) domain (PYHIN) receptors initiate the inflammatory response following cell stress or pathogenic challenge. When activated, some of these receptors oligomerize to form the structural backbone of a signalling platform known as an inflammasome. Inflammasomes promote the activation of caspase-1 and the maturation of the proinflammatory cytokines, interleukin (IL)-1β and IL-18. The gut dysregulation of the inflammasome complex is thought to be a contributing factor in the development of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD). The importance of inflammasomes to intestinal health has been emphasized by various inflammasome-deficient mice in dextran sulphate sodium (DSS) models of intestinal inflammation and by the identification of novel potential candidate genes in population-based human studies. In this review, we summarise the most recent findings with regard to the formation, sensing, and regulation of the inflammasome complex and highlight their importance in maintaining intestinal health.

Item Details

Item Type:Substantial Review
Keywords:inflammasomes, ulcerative colitis, Crohn’s disease, interleukin (IL)-1β, IL-18
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Ranson, N (Dr Nicole Ranson)
UTAS Author:Kunde, D (Dr Dale Kunde)
UTAS Author:Eri, R (Associate Professor Raj Eri)
ID Code:129746
Year Published:2018 (online first 2017)
Web of Science® Times Cited:14
Deposited By:Health Sciences
Deposited On:2018-12-17
Last Modified:2018-12-17

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