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129206 - Drosophila intestinal stem and progenitor cells.pdf (1.41 MB)

Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals

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posted on 2023-05-19, 22:33 authored by Doupe, DP, Owen MarshallOwen Marshall, Dayton, H, Brand, AH, Perrimon, N
Epithelial homeostasis requires the precise balance of epithelial stem/progenitor proliferation and differentiation. While many signaling pathways that regulate epithelial stem cells have been identified, it is probable that other regulators remain unidentified. Here, we use gene-expression profiling by targeted DamID to identify the stem/progenitor-specific transcription and signaling factors in the Drosophila midgut. Many signaling pathway components, including ligands of most major pathways, exhibit stem/progenitor-specific expression and have regulatory regions bound by both intrinsic and extrinsic transcription factors. In addition to previously identified stem/progenitor-derived ligands, we show that both the insulin-like factor Ilp6 and TNF ligand eiger are specifically expressed in the stem/progenitors and regulate normal tissue homeostasis. We propose that intestinal stem cells not only integrate multiple signals but also contribute to and regulate the homeostatic signaling microenvironmental niche through the expression of autocrine and paracrine factors.

History

Publication title

Proceedings of the National Academy of Sciences of The United States of America

Pagination

1-6

ISSN

0027-8424

Department/School

Menzies Institute for Medical Research

Publisher

Natl Acad Sciences

Place of publication

2101 Constitution Ave Nw, Washington, USA, Dc, 20418

Rights statement

Copyright 2018 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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