Ye, Y and Otahal, P and Marwick, TH and Wills, KE and Neil, AL and Venn, AJ, Cardiovascular and other competing causes of death among patients with cancer from 2006 to 2015: An Australian population-based study, Cancer pp. 1-11. ISSN 0008-543X (2018) [Refereed Article]
Copyright © 2018 John Wiley & Sons
Methods: The authors identified 21,637 individuals who had a first cancer registered between 2006 and 2013, with follow-up to 2015, in the Australian population-based Tasmanian Cancer Registry. The cumulative incidence of deaths from specific competing events was assessed in competing-risk analyses. Standardized mortality ratios (SMRs) and absolute excess risks (AERs) for deaths from noncancer causes were calculated for comparison with the general population.
Results: Overall, 8844 deaths were observed, with 1946 (22%) from competing events. The cumulative incidence of deaths from CVD increased significantly with age at first cancer diagnosis and exceeded other competing events at age ≥65 years. The risk of death from CVD was more common than expected in the first year of follow-up (SMR, 1.44 [95% confidence interval, 1.26-1.64]; AER, 36.8 per 10,000 person-years). The SMR and AER for CVD deaths varied by first cancer site, indicating increased risks after a first diagnosis of lung cancer, hematologic malignancy, and urinary tract cancer. For other noncancer events, the SMRs increased significantly for deaths from infectious disease and respiratory disease and were highest in the first year of follow-up.
Conclusions: CVD was the leading cause of competing mortality among Tasmanian patients with cancer who were diagnosed from 2006 to 2013. The higher than expected occurrence of death from CVD and other noncancer events during the first year after a cancer diagnosis highlights the importance of early preventive interventions.
|Item Type:||Refereed Article|
|Keywords:||cancer, cardiovascular mortality, competing risk, noncancer mortality, population-based|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Cardiovascular medicine and haematology|
|Research Field:||Cardiology (incl. cardiovascular diseases)|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Ye, Y (Ms Yuanzi Ye)|
|UTAS Author:||Otahal, P (Mr Petr Otahal)|
|UTAS Author:||Marwick, TH (Professor Tom Marwick)|
|UTAS Author:||Wills, KE (Dr Karen Wills)|
|UTAS Author:||Neil, AL (Associate Professor Amanda Neil)|
|UTAS Author:||Venn, AJ (Professor Alison Venn)|
|Web of Science® Times Cited:||8|
|Deposited By:||Menzies Institute for Medical Research|
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