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Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin’s lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy


Hanna, F and Prakash, A and Allan, E and Khalafallah, AA, Successful treatment of concomitant metastatic prostate cancer and B-cell non-Hodgkin's lymphoma with R-EPOCH chemotherapy regimen and antiandrogen therapy, BMJ Case Reports pp. 1-6. ISSN 1757-790X (2017) [Contribution to Refereed Journal]

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DOI: doi:10.1136/bcr-2017- 223637


A 70-year-old man presented with left loin pain without urinary symptoms. Initial investigations with CT showed enlarged para-aortic, mediastinal lymph nodes, rightside renal mass and enlarged prostate. A prostaticspecific antigen (PSA) was alarmingly high at 4750 μg/L (normal <4.0 μg/L). Further investigations included positron emission tomography (PET); both prostatespecific membrane antigen and 18-fluorodeoxyglucose as well as bone scan and bone marrow examination confirmed dual malignancies with B-cell non-Hodgkin’s lymphoma (B-NHL) and wide spread metastatic prostatic adenocarcinoma (PA ) to the skull, spine, pelvis, liver and lungs. The patient was treated with six cycles of rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin(R-EPOCH) containing regimen for B-NHL and goserelin hormonal therapy for PA . Restaging with PET scans thereafter showed complete remission of NHL with disappearance of his metastatic PA and normalisation of PSA levels. R-EPOCH regimen and antiandrogen therapy resulted in a good outcome and remission of both malignancies.

Item Details

Item Type:Contribution to Refereed Journal
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Hanna, F (Dr Fayez Hanna)
UTAS Author:Khalafallah, AA (Professor Alhossain Khalafallah)
ID Code:125432
Year Published:2017
Deposited By:Menzies Institute for Medical Research
Deposited On:2018-04-17
Last Modified:2018-04-17

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