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Membrane assisted and temperature controlled on-line evaporative concentration for microfluidics

journal contribution
posted on 2023-05-19, 17:20 authored by Fornells, E, Barnett, B, Bailey, M, Shellie, RA, Emily HilderEmily Hilder, Michael BreadmoreMichael Breadmore
A membrane evaporation concentrator for continuous flow conditions is introduced. The membrane evaporation concentrator provides nearly 30-fold concentration in less than 60 min whilst maintaining solute integrity under different sub-ambient pressure conditions and mild temperatures. To better understand the performance of the concentrator, a theoretical model was developed using caffeine as a model analyte, and used to predict the concentration performance of three target analytes at different conditions. An exponential relationship exists between temperature and concentration factor. By using the model it was determined that a 10-fold concentration (±0.5) can be performed at 56.72 ± 0.07 °C and at a flow rate of 10 μL min−1. Altogether, the model provides a better understanding of the process and ease of application in a wide variety of analytical methods. This work demonstrates that it is possible to obtain high concentrations with a continuously flowing fluid when temperature is precisely controlled and in times that are reasonable compared to existing evaporation concentration procedures.

History

Publication title

The Journal of Chromatography A

Volume

1486

Pagination

110-116

ISSN

0021-9673

Department/School

School of Natural Sciences

Publisher

Elsevier Science Bv

Place of publication

Po Box 211, Amsterdam, Netherlands, 1000 Ae

Rights statement

© 2016 Elsevier B.V. All rights reserved.

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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