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glass 2017 brain Abs in schizophrenia.pdf (4.74 MB)

Brain antibodies in the cortex and blood of people with schizophrenia and controls

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posted on 2023-05-19, 12:52 authored by Glass, LJ, Duncan SinclairDuncan Sinclair, Boerrigter, D, Naude, K, Fung, SJ, Brown, D, Catts, VS, Tooney, P, O'Donnell, M, Lenroot, R, Galletty, C, Liu, D, Weickert, TW, Shannon Weickert, C
The immune system is implicated in the pathogenesis of schizophrenia, with elevated proinflammatory cytokine mRNAs found in the brains of ~ 40% of individuals with the disorder. However, it is not clear if antibodies (specifically immunoglobulin-γ (IgG)) can be found in the brain of people with schizophrenia and if their abundance relates to brain inflammatory cytokine mRNA levels. Therefore, we investigated the localization and abundance of IgG in the frontal cortex of people with schizophrenia and controls, and the impact of proinflammatory cytokine status on IgG abundance in these groups. Brain IgGs were detected surrounding blood vessels in the human and non-human primate frontal cortex by immunohistochemistry. IgG levels did not differ significantly between schizophrenia cases and controls, or between schizophrenia cases in ‘high’ and ‘low’ proinflammatory cytokine subgroups. Consistent with the existence of IgG in the parenchyma of human brain, mRNA and protein of the IgG transporter (FcGRT) were present in the brain, and did not differ according to diagnosis or inflammatory status. Finally, brain-reactive antibody presence and abundance was investigated in the blood of living people. The plasma of living schizophrenia patients and healthy controls contained antibodies that displayed positive binding to Rhesus macaque cerebellar tissue, and the abundance of these antibodies was significantly lower in patients than controls. These findings suggest that antibodies in the brain and brain-reactive antibodies in the blood are present under normal circumstances.

Funding

National Health & Medical Research Council

History

Publication title

Translational psychiatry

Volume

7

Issue

8

Pagination

1-9

ISSN

2158-3188

Department/School

Wicking Dementia Research Education Centre

Publisher

Nature Publishing Group

Place of publication

United States

Rights statement

© The Author(s) 2017. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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