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Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study


Zhu, Z and Laslett, LL and Han, W and Antony, B and Pan, F and Cicuttini, F and Jones, G and Ding, C, Associations between MRI-detected early osteophytes and knee structure in older adults: a population-based cohort study, Osteoarthritis and Cartilage, 25, (12) pp. 2055-2062. ISSN 1063-4584 (2017) [Refereed Article]

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Copyright Statement

2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.This manuscript version is made available under the CC-BY-NC-ND 4.0 license

DOI: doi:10.1016/j.joca.2017.09.005


Objectives: To describe prevalence of osteophytes (OPs) detected only by magnetic resonance imaging (MRI) but not by standard X-ray in older adults and to evaluate longitudinal associations with knee structural changes.

Methods: 837 participants were randomly selected from the local community and had MRI scans to assess knee OPs and other structures. OPs detected only by MRI but not by standard X-ray were defined as MRI-detected early OPs (MRI-OPs for short). OPs detected by both MRI and X-ray were defined as established-OPs.

Results: The prevalence of MRI-OPs was 50% while the prevalence of established-OPs was 10% and no-OPs was 40% at total tibiofemoral (TF) compartment at baseline. Compared with no-OPs, participants with MRI-OPs had greater risks of increased cartilage defects in all TF compartments (RR 1.37, 95%CI 1.07-1.74) and bone marrow lesions (BMLs) only in medial TF compartment (RR 1.49, 95%CI 1.06-2.11), after adjustment for age, sex, BMI, cartilage defects, BMLs and/or joint space narrowing; participants with established-OPs had greater cartilage volume loss at total (β -2.02, 95%CI -3.86, -0.17) and lateral tibial sites (β -5.63, 95%CI -9.93, -1.32), greater risks of increased cartilage defects in total (RR 1.66, 95%CI 1.15-2.40) and medial TF compartments (RR 1.49, 95%CI 1.20-1.69) and BMLs in all TF compartments (RR 1.88, 95%CI 1.22-2.89), after adjustment for covariates.

Conclusion: MRI-OPs were associated with changes in knee structures, and the asscoiations were similar but not as prominent as those for established-OPs. These suggest MRI-OPs may have a role to play in knee early-stage osteoarthritic progression.

Item Details

Item Type:Refereed Article
Keywords:knee pain, knee structures abnormalities, magnetic resonance imaging, osteoarthritis, osteophytes
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Rheumatology and arthritis
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Zhu, Z (Mr Zhaohua Zhu)
UTAS Author:Laslett, LL (Dr Laura Laslett)
UTAS Author:Han, W (Dr Weiyu Han)
UTAS Author:Antony, B (Dr Benny Eathakkattu Antony)
UTAS Author:Pan, F (Dr Feng Pan)
UTAS Author:Jones, G (Professor Graeme Jones)
UTAS Author:Ding, C (Professor Chang-Hai Ding)
ID Code:121401
Year Published:2017
Web of Science® Times Cited:3
Deposited By:Menzies Institute for Medical Research
Deposited On:2017-09-27
Last Modified:2021-01-04
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