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Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic

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posted on 2023-05-22, 03:14 authored by Dianne NicolDianne Nicol, Lisa EcksteinLisa Eckstein, Morrison, M, Sherkow, JS, Margaret OtlowskiMargaret Otlowski, Whitton, T, Bubela, T, Kathryn BurdonKathryn Burdon, Donald ChalmersDonald Chalmers, Chan, S, Jac CharlesworthJac Charlesworth, Critchley, C, Crossley, M, de Lacey, S, Joanne DickinsonJoanne Dickinson, Alexander HewittAlexander Hewitt, Kamens, J, Kato, K, Kleiderman, E, Kodama, S, Liddicoat, J, David MackeyDavid Mackey, Newson, AJ, Jane NielsenJane Nielsen, Wagner, JK, Rebekah McWhirterRebekah McWhirter
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPRmediated somatic cell therapy.

History

Publication title

Genome Medicine

Volume

9

Article number

85

Number

85

Pagination

1-4

ISSN

1756-994X

Department/School

Faculty of Law

Publisher

BioMed Central Ltd.

Place of publication

United Kingdom

Rights statement

Copyright 2017 The Authors. Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Technological ethics; Law reform

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