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The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism


Kapoor, M and Clarkson, AN and Sutherland, BA and Appleton, I, The role of antioxidants in models of inflammation: emphasis on L-arginine and arachidonic acid metabolism, Inflammopharmacology, 12, (5-6) pp. 505-19. ISSN 0925-4692 (2005) [Refereed Article]

Copyright Statement

Copyright 2005 VSP

DOI: doi:10.1163/156856005774382797


Inflammatory processes are made up of a multitude of complex cascades. Under physiological conditions these processes aid in tissue repair. However, under pathophysiological environments, such as wound healing and hypoxia-ischaemia (HI), inflammatory mediators become imbalanced, resulting in tissue destruction. This review addresses the changes in reactive oxygen species (ROS), L-arginine and arachidonic acid metabolism in wound healing and HI and subsequent treatments with promising anti-oxidants. Even though these models may appear divergent, anti-oxidant treatments are nevertheless still having favourable effects. On the basis of recent findings, it is apparent that protection with anti-oxidants is not solely attributed to scavenging of ROS. In addition, the actions of anti-oxidants must be considered in light of the inflammatory process being assessed. To this end, there does not appear to be any universally applicable single mechanism to explain the actions of anti-oxidants.

Item Details

Item Type:Refereed Article
Keywords:wound healing, hypoxia-ischaemia, inflammation, EGCG, anti-oxidants, reactive oxygen species, cyclooxygenase, prostaglandins
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the health sciences
UTAS Author:Sutherland, BA (Associate Professor Brad Sutherland)
ID Code:113572
Year Published:2005
Deposited By:Medicine
Deposited On:2017-01-06
Last Modified:2019-03-29

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