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Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?

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posted on 2023-05-18, 23:11 authored by O'Toole, RF, Shukla, SD, Eugene WaltersEugene Walters
Expression of the platelet-activating factor receptor is upregulated in the respiratory epithelium of smokers and chronic obstructive pulmonary disease patients. We have recently determined that increased expression of PAFr correlates with higher levels of adhesion to human bronchial epithelial cells by non-typable Haemophilus influenzae and Streptococcus pneumoniae which are major bacterial pathogens in acute exacerbations of COPD. In addition, we found that a PAFr antagonist decreased the adhesion of both respiratory bacterial pathogens to non-cigarette exposure control levels. This highlights the possibility that epithelial receptors, that are upregulated in response to cigarette smoke, could be targeted to specifically block chronic bacterial infections of the lower respiratory tract. In this commentary, we explore the question of whether adhesion to a temporally-upregulated host receptor is a common event in chronic bacterial disease, and as such, could represent a putative therapeutic target for blocking infection by respiratory and other pathogens

History

Publication title

Journal of Translational Medicine

Volume

14

Article number

304

Number

304

Pagination

1-4

ISSN

1479-5876

Department/School

Tasmanian School of Medicine

Publisher

BioMed Central Ltd.

Place of publication

United Kingdom

Rights statement

Copyright 2016 The Authors Licensed under Creative Commons Attribution 4.0 International (CC BY 4.0) https://creativecommons.org/licenses/by/4.0/

Repository Status

  • Open

Socio-economic Objectives

Human pharmaceutical treatments

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