File(s) under permanent embargo
Stressful life events and the risk of initial central nervous system demyelination
OBJECTIVE: To examine the association between stressful life events and risk of first demyelinating event (FDE).
METHODS: This was a multicentre incident case-control study. Cases (n = 282 with first diagnosis of central nervous system (CNS) demyelination, including n = 216 with 'classic FDE') were aged 18-59 years. Controls without CNS demyelination (n = 558) were matched to cases on age, sex and study region. Stressful life events were assessed using a questionnaire based on the Social Readjustment Rating Scale.
RESULTS: Those who suffered from a serious illness in the previous 12 months were more likely to have an FDE (odds ratio (OR) = 2.35 (1.36, 4.06), p = 0.002), and when we limited our reference group to those who had no stressful life events, the magnitude of effect became stronger (OR = 5.41 (1.80, 16.28)). The total stress number and stress load were not convincingly associated with the risk of an FDE.
CONCLUSION: Cases were more likely to report a serious illness in the previous 12 months, which could suggest that a non-specific illness provides an additional strain to an already predisposed immune system.
History
Publication title
Multiple Sclerosis JournalVolume
23Issue
7Pagination
1000-1007ISSN
1352-4585Department/School
Menzies Institute for Medical ResearchPublisher
Sage Publications Ltd.Place of publication
United KingdomRights statement
Copyright 2016 The Author(s)Repository Status
- Restricted