File(s) under permanent embargo
Stability of left ventricular longitudinal and circumferential deformation over time and standard loading conditions
METHODS AND RESULTS: Baseline and a 12-month follow-up 2D echocardiograms were performed in 191 Stage A heart failure patients with uncomplicated hypertension. These patients underwent simultaneous measurement of conventional and central blood pressures (BPs) and haemodynamic measurements by applanation tonometry. Significant, but weak correlations (r = 0.15-0.28) of LV strain parameters and their changes over the follow-up period were shown for the majority of LV afterload-associated variables, including central and brachial systolic, diastolic, and mean BPs; 24-h systolic and diastolic BPs; peak reservoir and excess pressures; central augmented pressure (CAP) and pulse pressure; augmentation index; and arterial elastance index (EaI). Central mean BP, EaI, and changes in CAP and EaI over follow-up were independent contributors to LV deformation in multivariable analysis. No improvement in the Bland-Altman 95% limits of agreement and correlation coefficients was seen with LV afterload correction of GLS and GCS using central BP indices.
CONCLUSIONS: LV longitudinal and circumferential strains in a population without apparent heart disease is relatively insusceptible to changes in LV afterload within physiological range, which, therefore, seem unlikely to be a significant confounder in repeated GLS or GCS observations.
History
Publication title
European Heart Journal - Cardiovascular ImagingVolume
18Issue
9Pagination
1001-1007ISSN
2047-2404Department/School
Menzies Institute for Medical ResearchPublisher
Oxford University PressPlace of publication
United KingdomRights statement
Copyright 2016 The Author. Published on behalf of the European Society of Cardiology. All rights reserved.Repository Status
- Restricted