Amber, KI and Hadi, NR and Muhammad-Baqir, BM and Jamil, DA and Al-Aubaidy, HA, Trimetazidine attenuates the acute inflammatory response induced by Novolimus eluting bioresorbable coronary scaffold implantation, International Journal of Cardiology, 220 pp. 514-519. ISSN 0167-5273 (2016) [Refereed Article]
Copyright 2016 Elsevier Ireland Ltd.
Background: This study aims to investigate the inflammatory response in Novolimus bioresorbable coronary scaffold implantation after a course treatment with trimetazidine (35 mg tablet/twice daily for 4 days).
Methods: This was a randomized single blind study. Forty diabetic patients with critical coronary stenosis were subjected to elective coronary scaffold implantation in Al-Najaf Center for Cardiac Surgery and Trans-Catheter Therapy, Najaf, Iraq, between January and July 2015. All patients were informed about the nature of the study and they signed the consent form before they included in the study. Patients were randomly allocated into the two study groups: Group 1 included 20 patients who did the elective coronary scaffold implementation without trimetazidine medication. Group 2 included 20 patients who did the elective coronary scaffold implementation with a course of the trimetazidine (35 mg tablet/twice daily for 4 days).
Results: There were significant reduction in the levels of the interleukin-6 and cardiac troponin-I in the trimetazidine-treated group (group 2) compared to the control group (group 1) (P < 0.001), after 12 h and 24 h post-operative. This was associated with a significant rise in the levels of interleukin 10 in group 2 compared to group 1 (P < 0.001). Pentraxin-3 was significantly reduced in group 2 but only 24 h post-operative (P < 0.006).
Conclusion: Our study concluded that trimetazidine minimizes the acute inflammatory response occurred due to systemic release of inflammatory markers into blood in diabetic patients undergoing elective Novolimus bioresorbable coronary scaffold implementation.
|Item Type:||Refereed Article|
|Keywords:||trimetazidine, coronary artery disease, percutaneous coronary intervention, acute inflammation, interleukin-6, cardiac troponin-I, interleukin-10, pentraxin 3, C5a, bioresorbable coronary scaffold|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Medical biochemistry and metabolomics|
|Research Field:||Medical biochemistry - carbohydrates|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Jamil, DA (Dr Dina Jamil)|
|UTAS Author:||Al-Aubaidy, HA (Dr Hayder Al-Aubaidy)|
|Web of Science® Times Cited:||4|
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