Khalafallah, A and Phuah, E and Al-Barazan, AM and Nikakis, I and Radford, A and Clarkson, W and Trevett, C and Brain, T and Gebski, V and Corbould, A, Glycosylated haemoglobin for screening and diagnosis of gestational diabetes mellitus, BMJ Open, 6, (4) Article e011059. ISSN 2044-6055 (2016) [Refereed Article]
Licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/
SETTINGS: Primary health care. Single tertiary referral centre, Tasmania, Australia.
PARTICIPANTS: A direct comparison between HbA1c levels and the OGTT results in pregnant women, tested concurrently at the 24-28 gestational week, was undertaken. A full profile of 480 pregnant women during the period from September 2012 to July 2014 was completed. Median and mean age of participants was 29 years (range 18-47 years).
INTERVENTIONS: A simultaneous prospective assessment of HbA1c versus standard OGTT in a cohort of consecutive pregnant women presenting to our institute was performed.
RESULTS: The number of women who had GDM according to OGTT criteria was 57, representing 11.9% of the evaluated 480 pregnant women. Using a cut-off value for HbA1c at 5.1% (32 mmol/mol) for detecting GDM showed sensitivity of 61% and specificity of 68% with negative predictive value (NPV) of 93%, versus sensitivity of 27% and specificity of 95% with NPV of 91% when using HbA1c cut-off value of 5.4% (36 mmol/mol).
CONCLUSIONS: Our results suggest that pregnant women with an HbA1c of≥5.4% (36 mmol/mol) should proceed with an OGTT. This may result in a significant reduction in the burden of testing on both patients and testing facility staff and resources. Further investigations are required to integrate and optimise the HbA1c as a single, non-fasting, screening tool for GDM.
|Item Type:||Refereed Article|
|Research Division:||Biomedical and Clinical Sciences|
|Research Group:||Clinical sciences|
|Objective Group:||Clinical health|
|Objective Field:||Clinical health not elsewhere classified|
|UTAS Author:||Khalafallah, A (Professor Alhossain Khalafallah)|
|UTAS Author:||Al-Barazan, AM (Dr Abdul Majeed)|
|UTAS Author:||Corbould, A (Dr Anne Corbould)|
|Web of Science® Times Cited:||35|
|Deposited By:||Menzies Institute for Medical Research|
|Downloads:||202 View Download Statistics|
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