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Interaction of erythrocyte eicosapentaenoic acid and physical activity predicts reduced risk of mild cognitive impairment

journal contribution
posted on 2023-05-18, 19:42 authored by Street, SJ, Parletta, N, Milte, C, Sullivan, K, Andrew HillsAndrew Hills, Buckley, J, Howe, P

Objectives: To evaluate relationships between self-reported physical activity, proportions of long-chain omega-3 polyunsaturated fatty acids (LCn3) in erythrocyte content (percentage of total fatty acids) and risk of mild cognitive impairment (MCI) in older adults.

Method: A cross-sectional study was conducted. Community-dwelling male and female (n = 84) participants over the age of 65 years with and without MCI were tested for erythrocyte proportions of the LCn3s eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Physical activity was measured using a validated questionnaire.

Results: The interaction between erythrocyte EPA, but not DHA, and increased physical activity was associated with increased odds of a non-MCI classification.

Conclusion: An interaction between physical activity and erythrocyte EPA content (percentage of fatty acids) significantly predicted MCI status in older adults. Randomised control trials are needed to examine the potential for supplementation with EPA in combination with increased physical activity to mitigate the risk of MCI in ageing adults.

History

Publication title

Aging and Mental Health

Volume

19

Issue

10

Pagination

885-891

ISSN

1360-7863

Department/School

School of Health Sciences

Publisher

Carfax Publishing

Place of publication

United Kingdom

Rights statement

Copyright 2014 Taylor & Francis

Repository Status

  • Restricted

Socio-economic Objectives

Health related to ageing

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    University Of Tasmania

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