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Blood Pressure Variability and Prediction of Target Organ Damage in Patients With Uncomplicated Hypertension
METHODS: Mean BP levels (research-protocol clinic BP (clinic BP), 24-hour ambulatory BP, and 7-day home BP) and BPV were assessed in 286 patients with uncomplicated hypertension (mean age 64±8 SD years, 53% women) over 12 months. Reading-to-reading BPV (from 24-hour ambulatory BP) and day-to-day BPV (from 7-day home BP) were assessed at baseline and 12 months, and visit-to-visit BPV (clinic BP) was assessed from 5 visits over 12 months. LVMI was measured by 3D echocardiography and aPWV with applanation tonometry.
RESULTS: The strongest predictors of the changes in LVMI (ΔLVMI) were the changes in mean 24-hour systolic BPs (SBPs) (P < 0.02). Similarly, the strongest predictors of the changes in aPWV (ΔaPWV) were the changes in mean 24-hour ambulatory SBPs (P < 0.01) and the changes in mean clinic SBP (P < 0.001). However, none of the changes in BPV were independently associated with ΔLVMI or ΔaPWV (P > 0.05 for all).
CONCLUSIONS: Changes in mean BP levels, but not BPV, were most relevant to changes in TOD in patients with uncomplicated hypertension. Thus, from this point of view, BPV appears to have limited clinical utility in this patient population.
History
Publication title
American Journal of HypertensionVolume
29Issue
9Pagination
1046-1054ISSN
0895-7061Department/School
Menzies Institute for Medical ResearchPublisher
Oxford University PressPlace of publication
Great Clarendon St, Oxford, OX2 6DP United KingdomRights statement
Copyright 2016 American Journal of Hypertension, Ltd.Repository Status
- Restricted