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Matrix group structure and Markov invariants in the strand symmetric phylogenetic substitution model
We consider the continuous-time presentation of the strand symmetric phylogenetic substitution model (in which rate parameters are unchanged under nucleotide permutations given by Watson–Crick base conjugation). Algebraic analysis of the model’s underlying structure as a matrix group leads to a change of basis where the rate generator matrix is given by a two-part block decomposition. We apply representation theoretic techniques and, for any (fixed) number of phylogenetic taxa L and polynomial degree D of interest, provide the means to classify and enumerate the associated Markov invariants. In particular, in the quadratic and cubic cases we prove there are precisely 12(3L + (−1)L) and 6L−1 linearly independent Markov invariants, respectively. Additionally, we give the explicit polynomial forms of the Markov invariants for (i) the quadratic case with any number of taxa L, and (ii) the cubic case in the special case of a three-taxon phylogenetic tree. We close by showing our results are of practical interest since the quadratic Markov invariants provide independent estimates of phylogenetic distances based on (i) substitution rates within Watson–Crick conjugate pairs, and (ii) substitution rates across conjugate base pairs.
(This record is corrected by UTAS eCite record 145173)
Funding
Australian Research Council
History
Publication title
Journal of Mathematical BiologyVolume
73Pagination
259-282ISSN
0303-6812Department/School
School of Natural SciencesPublisher
Springer-VerlagPlace of publication
175 Fifth Ave, New York, USA, Ny, 10010Rights statement
Copyright 2015 Springer-Verlag Berlin HeidelbergRepository Status
- Restricted